Non-stimulant — alpha-2 adrenergic agonist
Kapvay
Clonidine (extended release)
Non-controlled
Pediatric ages 6+–17
How it works
Alpha-2 receptor agonist (less selective than guanfacine).
At-a-glance
- Onset of effect
- 168–336 h
- Typical duration of effect
- 12–24 h
- Half-life
- ~12–16
- Formulations
- Oral tablet (ER)
- Pediatric dose range
- 0.1–0.4 mg/day (BID)
Common side effects
- Sedation (more than guanfacine)
- Dry mouth
- Hypotension
- Fatigue
Important warnings
- Sedation can be significant — start at bedtime
- Do not stop abruptly
Notes
Often used for ADHD with sleep disturbance or tics. Adult use is off-label.
Source
Reference data is sourced from the current FDA prescribing information at DailyMed. Dose ranges, approved ages, and warnings change over time — always check the current label and consult your prescriber.